Radial Glia (neurogenic)

A glia cell type of the human nervous system.

Embryonic neural stem/progenitor cell (a glial-type cell, not a neuron) that generates cortical neurons and glia and forms a scaffold for migrating neurons during cortical development.

Function

Neural stem/progenitor cells that generate neurons and glia and provide radial scaffolds for neuronal migration.

Morphology

Elongated; bipolar (apical process to ventricle, basal process to pia)

Specification

  • Receptors: Notch; Wnt (self-renewal/fate signalling)
  • Location: Ventricular zone (embryonic cortex)
  • Projections: Long radial process to pial surface (basal); soma at ventricular surface (apical)
  • Firing: Non-spiking
  • Markers: PAX6; Nestin (NES); Vimentin (VIM); SOX2; HES1/HES5; BLBP/FABP7; GFAP in subsets
  • Developmental origin: Neuroepithelium / neuroectoderm (derived from neuroepithelial cells)
  • Disease: Microcephaly (progenitor depletion); cortical malformations (lissencephaly spectrum, periventricular heterotopia)
  • Cell Ontology: CL:0000681

References

  1. Noctor SC, Flint AC, Weissman TA, Dammerman RS, & Kriegstein AR (2001). Neurons derived from radial glial cells establish radial units in neocortex.. Nature 409 PMID 11217860
  2. Kriegstein A & Alvarez-Buylla A (2009). The glial nature of embryonic and adult neural stem cells.. Annual review of neuroscience 32 PMID 19555289
  3. Hevner RF (2019). Intermediate progenitors and Tbr2 in cortical development.. Journal of anatomy 235 PMID 30677129

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