Meningeal Fibroblast

A stromal cell type of the human nervous system.

Stromal (connective-tissue) cells of the meninges - the dura, arachnoid, and pia - that produce extracellular matrix, give the meningeal layers their structure, and help organize the immune, vascular, and lymphatic niches at CNS borders.

Function

Meningeal stromal cells that produce extracellular matrix, support meningeal structure, and help organize immune/vascular/lymphatic niches at CNS borders.

Morphology

Spindle-shaped, flat

Specification

  • Receptors: Cytokine receptors (specific receptors not individually sourced)
  • Location: Meninges - dura mater, arachnoid, and pia mater
  • Firing: Non-spiking
  • Markers: COL1A1/COL1A2; COL3A1; FN1 (fibronectin); DCN (decorin); LUM (lumican); PDGFRA; VIM (vimentin)
  • Developmental origin: Neural crest (forebrain meninges) / mesoderm (other regions)
  • Disease: Meningitis; Multiple Sclerosis (meningeal inflammation/fibrosis); fibrotic scarring after CNS injury
  • Cell Ontology: CL:4023058

References

  1. DeSisto J et al. (2020). Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function.. Developmental cell 54 PMID 32634398
  2. Dorrier CE, Jones HE, Pintarić L, Siegenthaler JA, & Daneman R (2022). Emerging roles for CNS fibroblasts in health, injury and disease.. Nature reviews. Neuroscience 23 PMID 34671105
  3. Louveau A et al. (2015). Structural and functional features of central nervous system lymphatic vessels.. Nature 523 PMID 26030524

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