Lugaro Cell

A neurons cell type of the human nervous system.

Cerebellar inhibitory interneuron strongly modulated by serotonin and positioned near the Purkinje cell layer.

Function

Serotonin-sensitive inhibitory interneurons that regulate Golgi-cell (and thus granule-layer) activity; serotonin drives sustained firing, acting as an intracortical switch patterning granule-layer information.

Morphology

Fusiform (spindle-shaped) soma, parasagittally oriented; long horizontal dendrites; partly myelinated transverse axons

Specification

  • Neurotransmitter: GABA (with glycine co-release)
  • Co-transmitters: Glycine (GABA and glycine co-released at Lugaro -> Golgi cell synapses)
  • Receptors: Serotonin receptors (Lugaro cells are selectively driven by serotonin)
  • Location: Cerebellar cortex, at the granular-layer / Purkinje-cell-layer border
  • Projections: Golgi cells (one Lugaro cell contacts >100 Golgi cells); parasagittal plexus + long transverse molecular-layer collaterals
  • Firing: Serotonin-driven sustained firing (~5-15 Hz)
  • Markers: CALB2/calretinin; GAD1/GAD2; SLC32A1/VGAT; SLC6A5/GlyT2 (glycinergic identity)
  • Developmental origin: Cerebellar ventricular zone
  • Disease: Cerebellar ataxia [association]
  • Cell Ontology: CL:0011006

References

  1. Dieudonné S & Dumoulin A (2000). Serotonin-driven long-range inhibitory connections in the cerebellar cortex.. The Journal of neuroscience : the official journal of the Society for Neuroscience 20 PMID 10684885
  2. Dumoulin A, Triller A, & Dieudonné S (2001). IPSC kinetics at identified GABAergic and mixed GABAergic and glycinergic synapses onto cerebellar Golgi cells.. The Journal of neuroscience : the official journal of the Society for Neuroscience 21 PMID 11487628
  3. Dieudonné S (2001). Serotonergic neuromodulation in the cerebellar cortex: cellular, synaptic, and molecular basis.. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 7 PMID 11499400

Loading interactive 3D atlas…