Basket Cell

A neurons cell type of the human nervous system.

GABAergic interneuron that wraps inhibitory synapses around principal-cell somata and helps generate fast network rhythms.

Function

Perisomatic inhibition of principal neurons; fast-spiking PV basket-cell networks help generate and synchronize gamma-frequency (~20-80 Hz) activity.

Morphology

Multipolar; dense basket-like axonal plexus surrounding target somata

Specification

  • Neurotransmitter: GABA
  • Co-transmitters: CCK in the CCK basket-cell subtype; N/A for parvalbumin (PV) basket cells
  • Receptors: AMPA; NMDA
  • Location: Cortex; Hippocampus; Cerebellum
  • Projections: Soma and proximal dendrites of principal cells (perisomatic axo-somatic synapses)
  • Firing: Fast-spiking (PV subtype); regular/accommodating (CCK subtype)
  • Markers: GAD1/GAD2; SLC32A1/VGAT; PVALB (fast-spiking subtype); CCK + CNR1/CB1 (CCK basket subtype)
  • Developmental origin: Medial ganglionic eminence
  • Disease: Epilepsy; Schizophrenia
  • Cell Ontology: CL:0000118

References

  1. Cardin JA et al. (2009). Driving fast-spiking cells induces gamma rhythm and controls sensory responses.. Nature 459 PMID 19396156
  2. Tremblay R, Lee S, & Rudy B (2016). GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits.. Neuron 91: 260–292 PMID 27477017

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